I love Pirates of the Caribbean.
Agreed. Nuf said 
Though alot of my friends, like morph are concerened about how the movie will do without the Orlando and Keira characters.
We'll just have to wait and see then, right?
Personally, I think it will not be as good as the others, but because everything else (besides Knightly and Bloom) is basically the same recipe, (Johnny Depp, Gore Verbinski, Jerry Bruckheimer, Hans Zimmer, etc) it will still be freaking awesome 
That reminds me of the fact that a lot (and I mean a lot) of people only went to see the second Transformers movie because Megan Fox was in it.
This isnt the case. I dont go to the movies to see Pirates of the Caribbean, just for Keira Knightly or Orlando Bloom.
But the latest movie just lost 2 of its main characters (Elizabeth and Will), and that is never a good thing.
And because these 2 MAIN characters (focus on the main part), are not some noob wanna-be actresses with big boobs who slept with the producer/director, but rather they are talented people who were in Pirates 1, 2 and 3, and helped the movie become a huge Hollywood blockbuster, then yeah, that is actually a small let-down for most people.
P.S. Maybe Penelope Cruz might be able to fill the gap of the female character in the movie (the gap that Keira left), even though she is playing a different character, but the absence of the young blacksmith, you loves a pretty girl, and is usually dragged into bad situations, remains.